Cells, Free Full-Text
4.5 (717) In stock
The close cooperation between breast cancer and cancer-associated adipose tissue (CAAT) shapes the malignant phenotype, but the role of mitochondrial metabolic reprogramming and obesity in breast cancer remains undecided, especially in premenopausal women. Here, we examined mitochondrial metabolic dynamics in paired biopsies of malignant versus benign breast tumor tissue and CAAT in normal-weight and overweight/obese premenopausal women. Lower protein level of pyruvate dehydrogenase and citrate synthase in malignant tumor tissue indicated decreased carbon flux from glucose into the Krebs cycle, whereas the trend was just the opposite in malignant CAAT. Simultaneously, stimulated lipolysis in CAAT of obese women was followed by upregulated β-oxidation, as well as fatty acid synthesis enzymes in both tumor tissue and CAAT of women with malignant tumors, corroborating their physical association. Further, protein level of electron transport chain complexes was generally increased in tumor tissue and CAAT from women with malignant tumors, respective to obesity. Preserved mitochondrial structure in malignant tumor tissue was also observed. However, mitochondrial DNA copy number and protein levels of PGC-1α were dependent on both malignancy and obesity in tumor tissue and CAAT. In conclusion, metabolic cooperation between breast cancer and CAAT in premenopausal women involves obesity-related, synchronized changes in mitochondrial metabolism.
Tarin-loaded nanoliposomes activate apoptosis & autophagy
Cells Free Full-Text Mitochondrial Haemoglobin Is, 48% OFF
Cells, Free Full-Text, freecell online 100
Cell-free, methylated DNA in blood samples reveals tissue-specific
Cells, Free Full-Text, wr games cell
Solved A cell-free extract of yeast known to contain all of
Cells, Free Full-Text, freecell online 100
Remote immune processes revealed by immune-derived circulating
Solved The globin protein can be synthesized in a cell-free
Formulation of YSD, a generic all-purpose serum- free medium for
Operations for gynecomastia in Tashkent at the Gatling Med clinic
- Peloton Apparel Women's Fitness Apparel & Athletic Wear – Tagged Bras – Peloton Apparel US
- ZARA WOOL BLEND CABLE-KNIT CARDIGAN Wool Cream Ornament Buttons size S SMALL £42.00 - PicClick UK
- CHARLEY HIGH LEG BRIEF - U R Beautiful Intimates
- PINK Victoria's Secret, Intimates & Sleepwear, Vs Pink Wear Everywhere Tshirt Lightly Lined Bra In Plum Color
- Princess Ariel Shell Planar
- Nike Dri-FIT Sport Essentials+ 10K2 Older Kids' (Girls') Running Shorts