Human Bladder Smooth Muscle Cells (HBdSMC)
5 (326) In stock
Isolated from human bladder tissue. HBdSMC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume.
The urinary bladder is a hollow organ made up of smooth muscle cells (SMC). The relaxation and contraction of urinary bladder smooth muscle allows the bladder to store and void urine, respectively. Phenotypic modulation of bladder SMC and the expression of inducible nitric oxide synthase are associated with various pathological conditions, including bladder dysfunction. Studies have shown that hypoxia inhibits human bladder SMC proliferation and bladder SMC differentiation is dependent on factors released from urothelial cells. The secretory phenotype of the bladder SMC extracellular matrix can be altered by the frequency of mechanical deformation experienced by these cells. SMC proliferation is a major contributing factor to the development and progression of a variety of diseases. As a result, understanding SMC changes during the genesis and maintenance of disease is vital to the development of therapeutic approaches.
HBdSMC from ScienCell Research Laboratories are isolated from human bladder tissue. HBdSMC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HBdSMC are characterized by immunofluorescence with antibodies specific to α-smooth muscle actin. HBdSMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HBdSMC are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Smooth Muscle Cell Medium (SMCM, Cat. #1101) for the culturing of HBdSMC in vitro.
Reversible differentiation of immortalized human bladder smooth muscle cells accompanied by actin bundle reorganization
Decellularized Scaffolds with Double‐Layer Aligned Microchannels Induce the Oriented Growth of Bladder Smooth Muscle Cells: Toward Urethral and Ureteral Reconstruction - Cheng - 2023 - Advanced Healthcare Materials - Wiley Online Library
Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition
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Reversible differentiation of immortalized human bladder smooth muscle cells accompanied by actin bundle reorganization
KR101800834B1 - Composition comprising anacardic acid for
Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells
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(IM-HBlSMC) provided by Innoprot have been developed by immortalizing primary human bladder smooth muscle cells with SV40 Large T antigen.,
Immortalized Human Bladder Smooth Muscle Cells
Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15 - ScienceDirect
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